Events > N > New Horizons in Biological Imaging
New Horizons in Biological Imaging
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Location:
Medical School, University of Oxford
Date:
07/04/2005 - 08/04/2005
Contact:
Clare Oxenbury
Tel:
01865 248768
Fax:
01865 791237
Email:
clare@rms.org.uk
Event Programme
This is a provisional programme
Thursday 7th April
9.30 Registration & Coffee
10.00 Aims and achievements of the Research Councils UK Basic Technology 'Deep Imaging' consortium
Prof. B. Vojnovic, (GCI)
10.30 Active and adaptive optics in microscopy
Prof T.Wilson, (Oxford) .
11.00 Progress towards deep tissue imaging with cost-effective light sources
Dr J. Girkin, (Strathclyde).
11.30 Progress towards measurement of temporal optical pulse distortion for optimised bioimaging
Simon Ameer-Beg
12.00 Summary and Discussion
12.15 Lunch, Exhibition and Poster session.
12.30 RMS LIGHT MICROSCOPY SECTION AGM
2.00 Nanoparticle labels for imaging and biossay:- present status and future prospects
Prof. Chris Morgan (Salford)
2.45 Lighting the way with lanthanide probes
Dr Andrew Beeby (Durham)
3.30 Fluorescent proteins in biology
Prof. Mike White (Liverpool)
4.15 Tea
4.45 Contributed paper
5.15 Summary and Discussion
5.30 Wine Reception, Exhibition and Poster Session
7.30 Conference Dinner at Hertford College
Friday 8th April
9.00 Coffee and Registration
9.15 Contributed papers
10.15 Surface Plasmon mediated fluorescence
Prof. Bill Barnes (Exeter)
11.00 Spatially Offset Raman Spectroscopy (SORS) for Subsurface Analysis of Materials
Dr Tony Parker (Rutherford)
11.45 Metal nano-optics for sensors
Prof. Alfred Leitner (Graz)
12.30 Summary and Discussion
12.45 Lunch, Exhibition and Poster Session
2.00 Characterization of sectioning fluorescence microscopy with thin uniform fluorescent layers: SIPcharts
Prof. G.J. Brakenhoff (Amsterdam)
2.45 Dyes with antennaeProf. Max Kreiter (Mainz)
3.30 Summary and Close
Event Description
This conference seeks to explore what is new and novel in biological labelling, sensing and imaging technology. New luminescent labels based on semiconductor 'quantum dots' are now commercially available and offer a number of advantages over conventional label technology, both as detectable markers and for 'FRET' applications. Newly developed methods of nanosecond imaging are particularly well suited to detection of quantum dots and have the potential for excellent background rejection. Colloidal metal nanoparticles of gold and silver are also under development and are easily detected by light scattering. Their properties can be tuned readily by variation of particle size and shape. Upconverting phosphor nanoparticles, which are excited efficiently by near infrared light but emit visible radiation, are also under active development. These materials hold much promise for assays and for labelling as the IR stimulus excites no detectable background at the power levels used.
Metal nanostructures also have profound effects on fluorescence of conventional fluorophores. The emerging field of 'radiative decay engineering' exploits these unusual effects for ultrasensitive detection of fluorescent labels for bioassay. In appropriate circumstances materials that normally have very low fluorescence efficiency can become much more fluorescent in close proximity to aggregated metal nanostructures for example. It is also possible to tailor the spatial distribution of emission to direct emission to a detector for optimum sensitivity. Metal nanostructures also have profound effects on the efficiency of Raman scattering and extraordinary sensitivity can be achieved in appropriate circumstances.
In parallel with these developments the techniques of multiphoton excitation are now well established and have opened up new areas of scientific imaging. In conjunction with adaptive optics, multiphoton imaging offers the potential for imaging of labels in optically dense tissues where light scattering and absorption would normally preclude effective measurement. Multiphoton imaging with adaptive optics and nanosecond time resolution can also be combined with the emerging label technologies and this has much promise for future applications in biosensing, imaging and medical diagnostics.
The conference brings together leading experts in the fields of imaging, sensing and label technology in an attractive and stimulating venue and the two-day format is designed to allow ample time for informal discussions between participants. The Conference should be of wide interest to participants across a range of disciplines in the life sciences and in the pharmaceutical sector including academic researchers and industrial scientists and managers. A limited number of contributed short talks and a poster session will complement the main presentations and a trade exhibition will allow attendees to see state-of-the-art equipment for imaging and sensing.
ORAL AND POSTER CONTRIBUTIONS ARE INVITED. ABSTRACTS OF NO MORE THAN 200 WORDS SHOULD BE EMAILED TO clare@rms.org.uk
