Cryo-EM beyond the Nobel

16 September 2019 - 20 September 2019

Scientific Organiser: Chris Parmenter (University of Nottingham)

There can be no doubt that Cryo-(T)EM is a hot topic following the 2017 Nobel Prize in Chemistry for its development. In fact many cryo-techniques have been around for over 40 years and are in use in both academic and industrial settings being applied to a full range of soft matter and materials samples beyond single particle analysis of proteins. This course looks to educate scientists and engineers to the full range of cryo-techniques, who are looking to characterise, analyse and understand structure / function of their samples where stabilisation of volatiles (often water) is required. Topics covered are expected to include:

  • Sample preparation / stabilisation (high-pressure freezing / plunge freezing)
  • Freeze-substitution / ultramicrotomy
  • Cryo-fluorescence microscopy / correlative microscopy
  • Cryo-TEM
  • Cryo-SEM / Cryo-FIB-SEM
  • Cryo X-Ray microscopy
  • Cryo-TOF-SIMS

The course will be delivered by an international group of world-renowned speakers, staff from the NMRC, Nottingham and representatives from many commercial partners. The course is a mix of both lecture style presentations and hands-on practical sessions, with plenty of opportunities to ask questions and explore the range of cryo-techniques on offer. By the end of the week attendees will have a good understanding of cryo-principles and appropriate usage of cryo-techniques as well as developing a network of contacts for the future.


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