Frontiers in BioImaging 2020
Scientific Organisers: Prof Mark Leake, Dr Leandro Lemgruber and Dr Theresa Ward
This is an ideal meeting for both new and established researchers to engage with a broad range of imaging approaches and to make valuable contacts with leading groups in the field. There will be an exhibition held alongside this meeting, where the tea, coffee, lunch and posters will all be held. We are very grateful to the exhibitors and their support.
Scroll down for further information on abstract submission, invited speakers, the provisional timetable, delegate information, and sponsors for this event.
Abstract Submission Deadline: Wednesday 8 April 2020
Abstract submission is now open. Abstracts should be emailed as an attachment to Kate Wooding, firstname.lastname@example.org. Please include in your email whether you would prefer to be considered for an Oral or Poster presentation.
- Please ensure you submit it as a Microsoft Word document and not a PDF
- Please ensure that you indicate your preference for a submitted talk or poster presentation
- Abstracts should be approximately 300-500 words in length , no longer than one page of A4
- Please include the title, all authors and their affiliations and indicate the presenting author
- You may include images or diagrams where appropriate
- You may also include references or keywords
The deadline for oral and poster abstract submissions is Wednesday 8 April 2020.
Imaging the immune response to cancer
Dr Leo Carlin
Leo Carlin studied immunology as an undergraduate at UCL and made his first attempts at fluorescence microscopy as a project student there. His passion for imaging immunology was cemented by trying to understand intercellular communication and regulation in highly-dynamic immune cells using advanced microscopy modalities first as a PhD student with Dan Davis at Imperial, then during post-docs with Tony Ng and Frédéric Geissmann at KCL. Leo’s group, initially at Imperial and now at the Cancer Research UK Beatson Institute try to understand how immune cell behaviour, heavily shaped by the context of specialised vascular beds like the lung and liver, influence the development and progression of cancer. He is also fortunate to lead the Beatson Advanced Imaging Resource (BAIR).
Accelerating drug discovery with the power of microscopy
Dr Anne Carpenter
Dr. Carpenter is an Institute Scientist at the Broad Institute of Harvard and MIT. Her research group develops algorithms and strategies for large-scale experiments involving images. The team’s open-source CellProfiler software is used by thousands of biologists worldwide (www.cellprofiler.org). Carpenter is a pioneer in image-based profiling, the extraction of rich, unbiased information from images for a number of important applications in drug discovery and functional genomics. Carpenter completed her postdoctoral fellowship at the Whitehead Institute for Biomedical Research and MIT’s Computer Sciences/Artificial Intelligence Laboratory (CSAIL). Her PhD is in cell biology from the University of Illinois, Urbana-Champaign. Carpenter has been named an NSF CAREER awardee, an NIH MIRA awardee, a Massachusetts Academy of Sciences fellow (its youngest at the time), a Genome Technology “Rising Young Investigator”, and is listed in Deep Knowledge Analytics’ top-100 AI Leaders in Drug Discovery and Advanced Healthcare.
Dr Carpenter will be giving the keynote presentation on Wednesday before the buffet dinner.
Quality and resolution in localisation microscopy
Dr Susan Cox
Light Microscopy Representative infocus Editorial Board
King's College London
Dr Susan Cox works at the Randall Centre for Cell and Molecular Biophysics, developing fluorescence microscopy techniques and applying them to discover new cell biology at the nanoscale. In 2011 she was awarded a Royal Society University Research Fellowship, which she used to develop a substantial research program based around localisation microscopy, and methods to extract more information from super-resolution image data. SC is best known as the developer of Bayesian analysis of blinking and bleaching (3B), a method for analysing extremely dense localisation microscopy image series. Its importance has been recognised with the award of the Royal Microscopical Society light microscopy medal and the Society of Experimental Biology Presidents Medal. More recently, she has explored the limits of localisation in terms of speed and accuracy. She mathematically described the role of the size of the point spread function size in limiting information transmission speed and developed a machine learning based approach to remove poor fits from the super resolution image. Since it is obviously more desirable to avoid poor fits in the first place, she developed Haar Wavelet Kernel analysis (HAWK), an approach to localisation microscopy data analysis which avoids artifacts and ensures the results reflect the underlying structure of the sample.
#smfBox: Democratising single-molecule FRET for dynamic structural biology
Dr Tim Craggs
University of Sheffield
Tim Craggs is a lecturer at the University of Sheffield, UK (appointed 2016). He is an expert in the development and application of Förster Resonance Energy Transfer (FRET) methods to biological systems, with particular experience in DNA-protein interactions. He completed his PhD (Cambridge, UK) developing single-molecule and ensemble methods to study protein folding. Subsequently, he helped to establish a new single-molecule lab (St Andrews) developing FRET approaches to study the structure-specific nucleases XPF and FEN1. He won a prestigious Lindemann Trust Fellowship to continue his investigation of DNA-protein interactions (specifically DNA Polymerase I) at Yale with Cathy Joyce (2010), and returned to the UK to work with Achillefs Kapanidis (Oxford, 2011) where he used smFRET to determine the structure and dynamics of a protein-DNA complex. His multidisciplinary skills span DNA and protein biochemistry, ensemble and single-molecule biophysics and molecular modelling. His current research is focussed on understanding the conformational dynamics of biomolecules.
The circle of life: image analysis for cell division in microbiology
Dr Siân Culley
Siân Culley is a postdoc in the Quantitative Imaging and Nanobiophysics group at the MRC Laboratory for Molecular Cell Biology at UCL. After doing an MSci project with Prof. Jonathan Ashmore in two-photon imaging of calcium signalling in inner hair cells, she moved into the field of super-resolution microscopy for her PhD with Dr Angus Bain investigating photophysical processes in CW-STED microscopy. In 2014 she joined Ricardo Henriques’ group, and her current research interests lie in developing open source hardware and analytics for live cell super-resolution microscopy. She also has an active interest in promoting women in microscopy.
Light and electron microscopy to study the function of axons and their myelinating cells
Dr Julia Edgar
University of Glasgow
Julia Edgar is a Senior Lecturer at the University of Glasgow and Visiting Staff Scientist at the Max Planck Institute of Experimental Medicine, Goettingen. She obtained her PhD in Developmental Neuroscience at the University of Edinburgh and held a Multiple Sclerosis Society Fellowship, before becoming a member of academic staff at Glasgow University. Her research focusses largely on how the myelinating cells of the central nervous system support the function and survival of the myelinated axon. She has expertise in several imaging methods including transmission electron microscopy and live cell imaging in vitro.
Monitoring target search of CRISPR-Cas in live bacteria
Dr Johannes Hohlbein
Wageningen University & Research
After obtaining a Ph.D. in Physics (2008, Martin Luther University Halle-Wittenberg, Germany), Johannes Hohlbein worked as a postdoc in the ‘Gene Machines’ group of Achilles Kapanidis at the University of Oxford. Since 2012 he is working in the Laboratory of Biophysics at Wageningen University & Research (The Netherlands), first as an assistant professor and currently as a tenured associate professor. His lab looks into the amazing world of DNA-protein interactions utilizing methods of single-molecule fluorescence spectroscopy and super-resolution microscopy.
Solving the code of intracellular calcium signalling with correlative localisation microscopy
Dr Izzy Jayasinghe
University of Leeds
Izzy Jayasinghe is a Lecturer and a UKRI Future Leader Fellow in the School of Biomedical Sciences in the University of Leeds. Her research has focused on developing new optical microscopy techniques for studying the organisation of the molecules of life, particularly proteins, within the heart. Prior to moving to Leeds, Izzy completed a PhD in Physiology in Auckland (New Zealand) and two postdoctoral fellowships in Queensland (Australia) and Exeter where she established a track record in developing and applying new optical imaging methods. In 2019, Izzy secured a UKRI Future Leader Fellowship with the aim of simplifying and applying contemporary super-resolution microscopy methods for field- and clinic-based investigations.
The axonal cytoskeleton at the nanoscale
Dr Christophe Leterrier
CNRS - Aix Marseille Université
After studying engineering at the École Supérieure de Physique et de Chimie Industrielles, Christophe Leterrier turned to biology and completed a Neuroscience PhD on cannabinoid receptor trafficking in neurons (2006). He then did a postdoc and obtained a research position in 2011, studying the organization of the initial segment of the axon in Marseille. In 2017, he started the NeuroCyto lab thanks at the Institute of Neurophysiopathology in Marseille. Following the discovery of new axonal actin structures: rings, hotspots and trails, the lab focuses its efforts on understanding their molecular organization and functions using a range of microscopy techniques, including super-resolution and correlative approaches.
The nanoscale organisation of T-cell membrane proteins in 3D
Dr Aleks Ponjavic
University of Leeds
Aleks obtained a PhD in Mechanical Engineering at Imperial College London, where he applied novel fluorescence microscopy techniques to study confined fluids. He then moved to the Chemistry department in Cambridge, where he worked on new single-molecule and light-sheet microscopy tools for investigating the behaviour and organisation of membrane proteins in T cells. In 2020, Aleks starts his own lab as a University Academic Fellow at the Bragg Centre for Materials Research in Leeds. Here, his lab will focus on the application of high-speed fluorescence imaging to push beyond the temporal limits of single-molecule and super-resolution fluorescence microscopy.
Tackling twist, single molecule insights into supercoiled DNA
Dr Alice Pyne
University of Sheffield
Alice Pyne is a Lecturer in Polymers/Soft Matter & MRC/UKRI Innovation Fellow in the Department of Materials Science and Engineering at the University of Sheffield. Alice has over a decade of experience in scanning probe microscopy, spanning high-speed and high-resolution imaging, probe development and cantilever sensing. Alice’s current research aims to understand how variations in DNA structure can affect fundamental biological processes such as replication and transcription. She uses high-resolution AFM to observe variability in structure and conformation in individual DNA molecules and to understand how these variations influence interactions with oligonucleotides and proteins, with a long-term view to improved development of therapeutics.
Light Sheet Imaging – a 15 years success story
Dr Emmanuel Reynaud
University College Dublin
Dr Emmanuel G. Reynaud is a Lecturer in Cell Biology at University College Dublin. After a PhD in Life Sciences from the University of Paris XI/Orsay, he received an EMBO Long Term Fellowship and moved to the European Molecular Biology Laboratory in Heidelberg Germany where he developed new methods in Cell Biology including laser nanosurgery approaches to study the Golgi biogenesis. He was later involved in the development of the Light Sheet based Fluorescence Microscopy as a member of the Light Microscopy Group headed by Ernst H.K. Stelzer. His laboratory is combining an R&D prototyping space and a cell biology laboratory to investigate the functions of epithelia in healh and diseases using a wide range of model systems from coral reefs to single vesicle. In 2014, he was awarded the Chevalier (Knight) of the Ordre des Palmes Académiques, one of the highest civilian honours bestowed on academics and educators by the French state.
Cryo-EM structures of tau filaments in neuro-degenerative disease
Dr Sjors Scheres
Sjors studied chemistry at Utrecht University, The Netherlands, where he also obtained his PhD in protein crystallography. He was a post-doc in the group of Jose-Maria Carazo in Madrid, before he started his group at the LMB in 2010. His main interest is currently in the development of new methods for high-resolution cryo-EM structure determination and in the cryo-EM structure determination of amyloid fibrils.
- 09:30 Arrival and meeting pack collection, Exhibition and Coffee
- 10:30 Welcome and Introduction
- Session One - Tissues and Organisms
Invited Speaker: The axonal cytoskeleton at the nanoscale
Christophe Leterrier, CNRS - Aix Marseille Université
Invited Speaker:The nanoscale organisation of T-cell membrane proteins in 3D
Aleks Ponjavic, University of Cambridge
- Lunch, Exhibition and Posters
- Session Two - Disease
Invited Speaker: Solving the code of intracellular calcium signalling with correlative localisation microscopy
Izzy Jayasinghe, University of Leeds
Invited Speaker: Light and electron microscopy to study the function of axons and their myelinating cells
Julia Edgar, University of Glasgow
- Tea, Coffee, Exhibition and Posters
- Session Three - Biocomputation
Invited Speaker:The circle of life: image analysis for cell division in microbiology
Siân Culley, UCL
Invited Speaker: Quality and resolution in localisation microscopy
Susan Cox, King's College London
Keynote Speaker: Accelerating drug discovery with the power of microscopy
Anne Carpenter, Broad Institute
- Drinks, Buffet Dinner, Posters and Exhibition
- 20:00 Day One Close
- Session Four - Biomolecules
Invited Speaker: Tackling twist, single molecule insights into supercoiled DNA
Alice Pyne, University of Sheffield
Invited Speaker: Cryo-EM structures of tau filaments in neuro-degenerative disease
Sjors Scheres, MRC-LMB
- Tea, Coffee, Exhibition and Posters
- Session Five – Correlative & Integrative
Invited Speaker:Imaging the immune response to cancer
Leo Carlin, Beatson Institute
Invited Speaker:Light Sheet Imaging – a 15 years success story
Emmanuel Reynaud, UCD Dublin
- Lunch, Exhibition and Posters
- Session Six – Democratizing bioimaging
Invited Speaker: Monitoring target search of CRISPR-Cas in live bacteria
Johannes Hohlbein, Wageningen University & Research
Invited Speaker: #smfBox: Democratising single-molecule FRET for dynamic structural biology
Tim Craggs, University of Sheffield
- Concluding Remarks
- 16:00 Tea and Coffee
- RMS Light Microscopy Section Annual General Meeting
- RMS Life Sciences Section Annual General Meeting
- RMS Electron Microscopy Section Annual General Meeting
Admittance to this event is for registered and authorised attendees. Unfortunately we cannot permit access to visitors or allow non-registered persons to enter the meeting or exhibition areas. If you have any questions, please contact the RMS contact for this event.
RMS Member £270
Any registrations made after Wednesday 27 May will incur a £50 late registration fee.
Registration closes on Wednesday 10 June.
The attendee pack collection will open from 9.30 am on Wednesday with the meeting starting at 10.30 am and will finish by 4.00 pm on Thursday.
Accommodation is not included in the event registration. We recommend you book your accommodation as early as possible.
On Wednesday 24 June there will be a buffet dinner at the venue, this is included in the registration fee for the Meeting.
For those registered an email will be sent to you three weeks before the event with final details.
Frontiers in BioImaging 2020 will take place at 15Hatfields, South Bank, London SE1 8DJ.
The nearest tube stations are: Southwark/Blackfriars/Waterloo
By agreeing to the terms and conditions of booking you have agreed to abide by the Code of Conduct set out for all attendees at RMS Events. If you would like to view the Code of Conduct, please visit https://www.rms.org.uk/terms-conditions/event-booking-terms-and-conditions.html. A copy will also be available at the registration desk at the event.
Hamamatsu Photonics is a world-leading manufacturer of opto-electronic components and systems and employs over 3000 staff worldwide. The corporate headquarters are based in Hamamatsu City, Japan along with various manufacturing plants and central research laboratories. Since its inception in 1953, Hamamatsu Photonics has expanded to now enjoy a global presence throughout Asia, Europe and North America.
Hamamatsu Photonics’ corporate philosophy stresses the advancement of Photonics through extensive research and development. Hundreds of new opto-electronic products are introduced to the market each year and many Hamamatsu products are regarded as state-of-the-art. Hamamatsu sources, detectors and imaging products are designed to cover the entire optical spectrum, from nuclear radiation, x-ray, Ultraviolet (UV), Visible and Infrared radiation. Hamamatsu devices provide solutions for a wide variety of applications including analytical, industrial and medical instrumentation.
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Nikon UK Ltd
Nikon Instruments is a leading manufacturer in light microscopy and metrology solutions. With over 100 years’ experience in optical design and a strong core technology group, Nikon has become a truly iconic brand for all types of imaging.
Nikon’s philosophy is to meet needs and exceed expectations. We specialise in the development of optical products, building an unbeatable reputation for lens technology and precision optics. We pride ourselves on providing high contrast, high definition, and aberration free images.
Find out more about Nikon UK Ltd
Photon Lines supplies a range of scientific cameras (including CCD cameras, CMOS and sCMOS), lasers and laser components which are optimised for Lightsheet microscopy. We also supply advanced scientific imaging solutions primarily into the area of biophotonics, such as Label-Free Live Cell Imaging Systems and fluorescence microscopy equipment including the products of PhaseView, who have engineered unique 3D imaging technologies for life science microscopy applications. Based on a novel remote focusing principle, PhaseView imaging products allow for high speed 3D imaging which is only limited by camera frame rate, while keeping bio-specimens in a stable position without moving the objective or stage. Using this acquisition principle, PhaseView’s Alpha3 light sheet fluorescence microscope addresses the issue of high temporal resolution along with spatial high-resolution, to achieve 3D imaging of dynamic biological processes.
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Find out more about MKS-Spectra Physics
Founded as Photometrics in 1978, Teledyne Photometrics is part of the Teledyne Imaging Group. Teledyne Photometrics is the world’s premier designer and manufacturer of high-performance CMOS, EMCCD and CCD cameras for life science research. The original architect of the world’s first scientific-grade microscopy EMCCD camera and developer of the popular CoolSNAP CCD cameras, Teledyne Photometrics maintains its leadership role with the release of Prime, the first sCMOS camera with built-in computational intelligence for image restoration, and Prime 95B, the first sCMOS camera with 95% quantum efficiency. Teledyne Photometrics also offers comprehensive OEM support, including fully characterized, cost-efficient imaging systems and components. Teledyne Photometrics is headquartered in Tucson, Arizona.
Find out more about Teledyne Photometrics
If you are interested in exhibiting at this event, please contact Kat Driscoll.
Book a place
- £270 Member rate
- £320 Non-Member rate
- £170 Student rate