Imaging ONEWORLD - "How do human cells divide? Developing microscopy methods to extend the frontiers of imaging photosensitive samples."
27 September 2021
This week will feature Viji Mythily Draviam from Queen Mary, University of London.
Scientific Organisers: Stefanie Reichelt, Alex Sossick, Nick Barry, Alessandro Esposito and Kirti Prakash
The meeting will begin at 1pm UK Time.
As part of the 'Imaging ONEWORLD' series, the focus of these lectures is on microscopy and image analysis methods and how to apply these to your research. Almost all aspects of imaging such as sample preparation, labelling strategies, experimental workflows, ‘how-to’ image and analyse, as well as facilitating collaborations and inspiring new scientific ideas will be covered. Speakers will be available for questions and answers. The organisers, CRUK CI core facility staff, Gurdon Institute, MRC-LMB, MRC Cancer Unit and NPL will be able to continue the discussion and provide advice on your imaging projects.
Professor Viji Draviam
Queen Mary, University of London
Viji Mythily Draviam is a Professor of Quantitative Cell and Molecular Biology at Queen Mary, University of London. Her research considers the molecular mechanisms that underpin cell division. Following a PhD at the University of Cambridge and a postdoctoral research work at Harvard Medical School and the Massachusetts Institute of Technology, Viji returned to Cambridge in 2008 to establish her research group studying chromosome segregation mechanisms. In 2015, her group moved to QMUL and has contributed significantly to the development of imaging tools to track and analyse the behaviour of subcellular structures in highly photosensitive samples. Viji leads the Center for Cell Dynamics, a consortium of 27 investigators collaboratively exploring super-resolution microscopy methods for dynamic studies of cells and organisms.
When cells divide, chromosomes must be pulled apart into two equal sets. Microtubules of the mitotic spindle capture chromosomes at a specialised site called the kinetochore. To understand kinetochore structure and function its important to track these submicron structures, through time, in 3D. Similar microtubule attachment sites at the cell cortex aid the rotation and movement of spindles. I will present high-resolution image acquisition methods and image analysis tools developed in the group to study chromosome capture and spindle rotation processes in detail.