Imaging ONEWORLD - 'Illuminating Biochemical Activity Architecture of the Cell.' - Professor Jin Zhang


Scientific Organisers: Stefanie Reichelt, Alex Sossick, Nick Barry, Alessandro Esposito and Kirti Prakash

The meeting will begin at 1pm GMT.

As part of the 'Imaging ONEWORLD' series, the focus of these lectures is on microscopy and image analysis methods and how to apply these to your research. Almost all aspects of imaging such as sample preparation, labelling strategies, experimental workflows, ‘how-to’ image and analyse, as well as facilitating collaborations and inspiring new scientific ideas will be covered. Speakers will be available for questions and answers. The organisers, CRUK CI core facility staff, Gurdon Institute, MRC-LMB, MRC Cancer Unit and NPL will be able to continue the discussion and provide advice on your imaging projects.


Speaker

  • Prof Jin Zhang

    University of California, San Diego

    Prof Jin Zhang received her PhD in Chemistry from the U. Chicago.  After completing her postdoctoral work at University of California, San Diego (UCSD), she joined the faculty of Johns Hopkins University School of Medicine in 2003. She was promoted to Professor in 2013. In 2015 she moved back to UCSD and is currently a Professor of Pharmacology, Bioengineering and Chemistry & Biochemistry. Research in her lab focuses on developing enabling technologies to probe the active molecules in their native environment and characterizing how these active molecules change in diseases including cancer. Professor Zhang is a recipient of the NIH Director’s Pioneer Award (2009), the John J. Abel Award in Pharmacology from ASPET (2012), the Pfizer Award in Enzyme Chemistry from ACS (2012), and the Outstanding Investigator Award (2015) from NCI. She was elected as a Fellow of AAAS in 2014 and a Fellow of AIMBE in 2019.


Speaker's Abstract

The complexity and specificity of many forms of signal transduction are widely suspected to require spatial microcompartmentation and dynamic modulation of the activities of signaling molecules, such as protein kinases, phosphatases and second messengers. We have developed a series of fluorescent biosensors to probe the compartmentalized signaling activities in living cells. In this talk, I will discuss a suite of newly developed fluorescent biosensors and present a study where we applied these genetically encoded fluorescent biosensors to probe the biochemical activity architecture of the cell.