Speakers
Keynote
Microscopy is underpinning key discoveries in Biomedical research. For instance, live light microscopy can show us the dynamics of a system. On the other hand, Electron Microscopy (EM) gives us better resolution combined with an ultrastructural reference space. Correlative Light Electron Microscopy (CLEM) combines the strengths of light and electron microscopy in one experiment and the sum of such an experiment should provide more data / insight than each technique alone (hence 1 + 1 = 3). There are many ways to perform a CLEM experiment and a variety of microscopy modalities can be combined. The choice of these instruments and the experimental approach should primarily depend on the scientific question to be answered. The Verkade lab aims to develop and apply correlative imaging approaches to a broad range of biological questions.
In the seminar I will discuss some of our correlative imaging approaches, each tailored to their specific biological question. These range from cryo CLEM to extract molecular data to Volume EM (vEM) based techniques to establish connectivity and the broader context of a structure of interest.