Invited Speaker
Early detection of clear cell renal cell carcinoma (ccRCC) remains challenging due to a reliance on incidental imaging. Building on immune signatures identified in other cancers, we developed two high-parameter spectral cytometry panels to characterize the systemic T- and B-cell landscape in ccRCC. Our analysis revealed a systemic shift from naïve to central memory T cells in ccRCC patients, alongside widespread promoter hypermethylation suggestive of coordinated transcriptional repression. By integrating these cellular and epigenetic features into a multi-omic model, we observed a preliminary ability to distinguish ccRCC from benign oncocytoma. These findings suggest that systemic T-cell remodelling and epigenetic signatures warrant further investigation as potential non-invasive biomarkers for early ccRCC.