Using Peptide-Drug Conjugates (PDCs) for the Precise Treatment of Pulmonary Fibrosis
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Dr. Kelly and her colleagues synthesized a panel of PDCs aiming at the precise treatment of pulmonary fibrosis, where nintedanib - a potent kinase inhibitor approved for the treatment of idiopathic pulmonary fibrosis - and a peptidomimetic targeting αVβ6 integrin - which is a receptor overexpressed in fibrotic tissues - are connected by different linkers. Given the promising in vitro results of one synthesized PDC, the in vivo antifibrotic activity is currently under evaluation in mice models of pulmonary fibrosis.
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