Age-dependent changes of alpha-Synuclein in the motor cortex (infocus #81 March 2026)

Alpha-synuclein (aSyn) is a protein found within the nerve cells of the brain.

DOI: 10.22443/rms.inf.1.309

This protein controls the release of nerve signals and interacts with other nerve proteins to regulate neural function (Emamzadeh, 2016).

Abnormal accumulations of aSyn lead to the brain disorder Parkinson’s Disease (PD) (Van Den Berge et al., 2021). PD, generally associated with older age, causes difficulties with movement, as well as behavioural and functional symptoms (Bloem, Okun and Klein, 2021).

Despite its significance, the role of aSyn within the body and ageing process remains unclear. Here we used young (3-months) and older (12-months) mice to investigate how the expression of aSyn and 2 other nerve proteins Synapsin-1 (Syn1) and Homer1 (H1) change with age.

Return to listing