Detection and characterisation of three-dimensional specularly reflecting objects such as microbubbles through tissue (infocus #81 March 2026)

DOI: 10.22443/rms.inf.1.312

Through preclinical and clinical studies, Acoustic Cluster Therapy (ACT) has demonstrated success in enhancing chemotherapy efficacy while reducing drug toxicity, compared to conventional passive transvascular drug delivery.[1][2][3] ACT consists of negatively charged microbubbles (Sonazoid™) and positively charged microdroplets, which form clusters via electrostatic interaction.

These clusters, along with the administered drug, are activated by ultrasound to temporarily lodge in tumor capillaries, improving local drug delivery. However, the biomechanical mechanisms underlying ACT-induced enhancement of drug extravasation remain unexplored.