Biomedical Imaging Unit, Southampton

The Biomedical Imaging Unit, is a joint University Hospitals Southampton NHS Foundation Trust (UHS)/University of Southampton (UoS) facility for high quality/high resolution diagnostic and research microscopy. Accredited under UKAS to ISO 15189, this core facility carries out research work for UoS, other universities and research institutes, industry and artists, together with diagnostic microscopy for UHS, and other hospitals both nationally and internationally.



Expertise

Imaging Platforms

Keywords - Light Microscopy: Confocal microscopy | Widefield microscopy | Laser microdissection | Live cell imaging | Light-sheet microscopy (SPIM) | Virtual slide scanning microscopy

Keywords - Electron Microscopy: Transmission EM | Scanning Transmission EM | Electron tomography | Scanning EM (Tungsten) | Serial Block Face SEM | X-ray microanalysis 

Keywords - X-Ray Microscopy: MicroCT

The Biomedical Imaging Unit is extremely well equipped, housing a range of instruments including light, electron and x-ray microscopy in 2- 3- and 4-dimensions.

Applications

Keywords - Biological: Cell Biology | Neurobiology | Developmental Biology | Immunobiology | Plant Biology | Zebrafish| C.elegans | Drosophila | Microbiology | Bio-materials | Histology/pathology | Food | Diagnostic microscopy

Keywords - Physical Sciences: Bioengineering & biomaterials | Metallurgy/Alloy Development | Functional oxides | Nanomaterials | Geology/Mineralogy

Sample Preparation

Keywords - Biological: Resin embedding | Ultrathin sectioning | Serial sectioning | Tokuyasu embedding | Immunolabelling | Critical Point Drying | Metal coating | Negative stain | Correlative Light & EM | PLT | Immunofluorescence | Cryostat sectioning | Vibrating microtome | H&E staining | Enzyme histochemistry | Live Cell

Data Analysis

Keywords - Software: ImageJ | FIJI | Amira | IMOD | Matlab | Volocity | Digital Micrograph/ GMS

Shared Access

As a multi-user facility supported by 8 highly experienced and expert imaging staff, the Biomedical Imaging Unit can provide a complete supporting workflow for internal and external users in all aspects of imaging from experimental design, proof of concept tests, user training, sample preparation, imaging, interpretation, processing and analysis of specimens, data management and archiving.

We also provide training both on a one to one basis and in more formal courses.

Funding

We are happy to discuss imaging requirements and access charges. 



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