22 Mar 2022

Winner of 2022 RMS Early Career Award announced!

Congratulations to Katherine Paine, of the University of York

The RMS is delighted to announce the 2022 winner of the Early Career Award as Katherine Paine, of the University of York.
Katherine, who began her PhD in 2018 at Chris MacDonald’s laboratory, was chosen in recognition of the novel approaches in imaging and cytometry she has brought to her studies on the regulation of cell surface membrane proteins.
She will receive a £100 cash prize and an invitation to deliver a keynote presentation at Microscopy: Advances, Innovation, Impact 2022 – an event which includes the RMS Annual General Meetings.
RMS Early Career Committee Chair, Liam Rooney said: “Not only have Katherine’s approaches allowed her to discover novel mechanisms related to surface protein trafficking in yeast, but these methods can now be used by others in the field in the future. It is a privilege to commend her achievements with this award.”
More about Katherine’s work
Cell surface membrane proteins perform diverse and critical functions and are spatially and temporally regulated by membrane trafficking pathways. These trafficking pathways are evolutionary conserved from yeast to humans. MacDonald lab uses yeast as a model organism to study these pathways.
It became clear from Katherine’s initial studies that although standard confocal microscopy could be used to visualise some of the processes she was interested in, there were also limitations. She then helped optimise a suite of imaging and cytometry approaches to study surface proteins. This includes Airyscan2, structured illumination (SIM) and photoactivated localisation microscopy (PALM); all of which can be coupled to bespoke microfluidic exchange systems.
Katherine is also in the process of optimising a high throughput method to measure Förster resonance energy transfer (FRET) in yeast using robotics and flow cytometry.

Find out more about the RMS Early Career Award