Aberystwyth University Advanced Microscopy and Bio-imaging Laboratory

The current Advanced Microscopy and Bio-imaging Laboratory was established in 2002. It is based in the refurbished Electron Microscope Facility which has been in existence since the mid 1960's and is located on the ground floor of the Edward Llwyd Building on Penglais Campus.



Expertise

Imaging Platforms

Keywords - Light Microscopy: Laser microdissection | Live cell imaging | PALM | Confocal Microscopy | Raman imaging

Keywords - Electron Microscopy: Transmission EM | Scanning EM (FEG)

The laboratory has three electron microscopes (Hitachi S-4700 Field Emission Scanning Electron Microscope, JEOL JEM1010 Transmission Electron Microscope, JEOL 840A Cryo Scanning Electron Microscope).
For advanced light microscopy techniques we have a Leica TCS SP5 Laser Confocal Scanning Microscope and a Leica LMD6000 Laser Microdissection Microscope.

A Leica TCS SP8 HyVolution 2 super-resolution Laser Confocal Scanning Microscope, a Renishaw inVia Raman Microscope and a variety of fluorescence, polarising and interference contrast microscopes are also available.

Applications

Keywords – Biological: Cell Biology | Plant Biology | Microbiology | Histology/Pathology | Drosophila | Bio-materials | Food

Keywords - Physical Sciences: Bioengineering & Biomaterials | Geology/Mineralogy | Nanomaterials

We image a range of Biological, Geological and Materials Science samples. 

Sample Preparation

Keywords - Biological: Resin embedding | Cryosectioning | Plunge freezing | Critical point drying | Metal coating | Immunofluorescance | Ultrathin sectioning | Immunolabelling | Freeze fracture | Negative stain | Live cell

Comprehensive specimen preparation facilities include Leica EM MM80E “Slam” freezer, AFS freeze substitution apparatus, Leica CM3050S cryostat, and various ultramicrotomes for TEM and light microscopy sectioning.



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